發布日期:2020/2/24 9:51:53
DOI: 10.1021/jacs.9b09189

ABSTRACT: Covalent organic frameworks (COFs) represent a new class
of porous crystalline polymers with a diversity of applications. However,
synthesis of uniform spherical COFs poses a great challenge. Here, we
present size-controllable synthesis of uniform spherical COFs from
nanometer to micrometer scale by a facile approach at room temperature.
The as-prepared spherical COFs with difffferent sizes exhibited ultrahigh
surface area, good crystallinity, and chemical/thermal stability. Multi
farious microscopic and spectroscopic techniques were performed to
understand the formation mechanism and inflfluencing factors of the
spherical COFs. Moreover, the general applicability for room-temperature
synthesis of the spherical COFs was demonstrated by varying difffferent
building blocks. Spherical COFs, because of the advantageous nature of
their surface area, hydrophobicity, and mesoporous microenvironment,
serve as an attractive restricted-access adsorption material for highly selective
and effiffifficient enrichment of hydrophobic peptides and size exclusion
of macromolecular proteins simultaneously. On this basis, the spherical COFs
were successfully applied to the specifific capture of ultratrace C-peptide from
human serum and urine samples. This research provides a new strategy for room
temperature controllable synthesis of uniform spherical COFs with difffferent 
sizes and extends the application of COFs as an attractive sample-enrichment probe for clinical analysis.



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